7-乙基-10-羥基喜樹堿7-Ethyl-10-Hydroxycamptothecin（SN-38）

Product Name: 7-Ethyl-10-Hydroxycamptothecin(SN-38); SN 38   7-乙基-10-羥基喜樹堿
CAS No.: 86639-52-3
Chemical Name: (4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizi,2-b]quinoline-3,14(4H,12H)dione
Molecular formula: C₂₂H₂₀N₂O₅
Molecular weight: 392.40
Physical and chemical properties: 7-Ethyl-10-Hydroxycamptothecin is pale yellow to yellow crystalline powder, soluble in DSMO, methanol and ethanol. Not soluble in water and chloroform.
Strorage: Store in a cool and dry area, sealed and keep from direct light
Indication: It can be used in the treatment for non-small-cell lung cancer, rectum cancer and also can be used as the intermediates of Irinotecan

Appearance: White to light yellow crystalline powder
Assay (On dried basis):>99%    

Usage: Irinotecan Intermediate; A metabolite of Irinotecan, a DNA topoisomerase inhibitor.

Biological Activity: Active metabolite of CPT-11  that inhibits DNA topoisomerase I (IC₅₀ values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC₅₀ values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC₅₀ values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).